The five-bedroom home, on Manchester Road in Crosspool, spans three floors and backs onto woodland.
A spokesman for ELR Sheffield, which is marketing the property for £850,000, said: “A beautiful and spacious 1920s family home located on the edge of the city limits and yet also convenient for the excellent amenities in Crosspool, highly regarded schooling and the main city hospitals and universities.
“Den Bank House has a range of versatile accommodation over three floors including a number of rooms in the basement and a superb ground floor footprint, ideal for the larger families.
“Set well back from the road beyond a wide block paved driveway and having a pleasing aspect to the rear over woodland, this splendid five double bedroom home will be sure to impress.”