The Owls side could include the return of a handful of previously injured players, with the likes of Dominic Iorfa, Tom Lees and Izzy Brown nearing a return.
Our man Alex Miller has weighed into the debate to name his side to topple his namesakes this evening.
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1. GK - Cameron Dawson
Should surely keep his place as Wednesday look to instil some consistency in selection at the back as and when injury recoveries begin to fall into place. Photo: Steve Ellis
2. CB - Julian Borner
Borner's long-awaited chance on the left of the back three could hang on Tom Lees' condition. It would be harsh on the German, who appears to be a long way down the pecking order all of a sudden, but Wednesday can't concern themselves with 'fair' right now - points are what's needed. Photo: Steve Ellis
3. CB - Aden Flint
The big man has made an excellent start to life at Hillsborough and should continue in that vein. He's a threat in both boxes and if delivery can improve - is a goal threat. Photo: Steve Ellis
4. CB - Dominic Iorfa
IF - and it remains a big if - Iorfa is fit, then Garry Monk will surely be tempted to slot him straight in on the right of his back three. Moses Odubajo was shoehorned in during his absence with a hamstring injury - they missed Iorfa's positioning and recovery ability. Photo: Stu Forster