The Blades picked up their first win of the season in any competition when they beat the Pirates earlier this month, but they certainly didn’t have things their own way for large spells in that clash.
Pegged back twice by their League One opponents, it was Jayden Bogle who eventually netted the decisive strike in a tight 3-2 win.
This weekend represents another banana skin for Wilder's struggling side too.
Plymouth are 15th in League One, and with promotion hopes and relegation fears both looking like relatively distant prospects this term, Argyle could be looking at a potential giant-killing as a means of injecting some excitement into their campaign.
It wasn’t that long ago that the two sides met in the FA Cup either.
The Blades and the Pilgrims met in the second round of the competition back in 2014, with United coming out on top in a comfortable 3-0 win.
Jose Baxter was the man of the hour that day, scoring twice from the penalty spot before substitute Marc McNulty bagged a goal of his own in the final minute.
Nigel Clough’s men went on to have a decent cup run that year too, beating QPR in the next round and forcing Preston North End to a replay before being knocked at Bramall Lane.
Here’s what happened to every member of the Blades’ starting XI from the last time they faced off against Plymouth Argyle:
![The 34-year-old stopper left Sheffield United in 2016, and after spells at Bolton Wanderers, Blackpool, and Salford City, now plies his trade at Scunthorpe United. (Photo by GLYN KIRK/AFP via Getty Images)](https://www.thestar.co.uk/webimg/b25lY21zOmU1MTc1ZmRjLTY0NDgtNGYyMi04MTAyLWU2ZDA5ZDQzY2MzMjpiMjlhNTBlNi0xMzQxLTQ2NDQtYTJiMS1mMzNhZTdlYTVjMGE=.jpg?crop=3:2&width=640)
1. Mark Howard
The 34-year-old stopper left Sheffield United in 2016, and after spells at Bolton Wanderers, Blackpool, and Salford City, now plies his trade at Scunthorpe United. (Photo by GLYN KIRK/AFP via Getty Images) Photo: GLYN KIRK
![The defender hung up his boots in 2019 after a stint in non-league football. His final club was FC United of Manchester. (Photo by Clive Mason/Getty Images)](https://www.thestar.co.uk/webimg/b25lY21zOjU2ODMzZDg1LTVmODQtNDJjNy1iOTFkLTQ2MGNhOTE2ZjMzYTo0NmFlMzhlZC1mNGJmLTRhNDYtODg0OC0xZjFmYTA3Mzk5ZTA=.jpg?crop=3:2&width=640)
2. Bob Harris
The defender hung up his boots in 2019 after a stint in non-league football. His final club was FC United of Manchester. (Photo by Clive Mason/Getty Images) Photo: Clive Mason
![Another player who has retired in recent years, McEveley called time on his career in 2018 after spells with Ross County, Tranmere Rovers, and Warrington Town. (Photo by Tony Marshall/Getty Images)](https://www.thestar.co.uk/webimg/b25lY21zOjg0MTcxYjEzLTY2MDktNDMyNy05YjM3LTNkN2Y5MDYzNzU3YzphZjFkYWUxMC03ZDAxLTRhNjAtODBmMi02MjY3OTkwYmQ4MjY=.jpg?crop=3:2&width=640)
3. Jay McEveley
Another player who has retired in recent years, McEveley called time on his career in 2018 after spells with Ross County, Tranmere Rovers, and Warrington Town. (Photo by Tony Marshall/Getty Images) Photo: Tony Marshall
![The only survivor from that starting XI seven years ago, Basham is still a key member of the Blades' squad. The 32-year-old has played in every single one of United's Premier League matches this season. (Photo by Mike Egerton - Pool/Getty Images)](https://www.thestar.co.uk/webimg/b25lY21zOmMzOTc2Yjk3LTFkMjctNDUyNy1hOTkzLTkxMjkxYzE0MjNkNDpjMzJlODhmMy1iMmFhLTRhZDktOTJkMC05NzU3YmU3ZDQyYzI=.jpg?crop=3:2&width=640)
4. Chris Basham
The only survivor from that starting XI seven years ago, Basham is still a key member of the Blades' squad. The 32-year-old has played in every single one of United's Premier League matches this season. (Photo by Mike Egerton - Pool/Getty Images) Photo: Pool