Boro travel to Bramall Lane sixth in the Championship, a point and a place ahead of United, and both sides know that three points would represent a big statement of intent as the race for the top six prepares to enter the final straight.
United hope for the return of George Baldock after injury, while Wilder and Boro are sweating over the fitness of Australian star Riley McGree ahead of the Blades clash.
We tasked our man Danny Hall to step into Paul Heckingbottom’s shoes and select the side he would send out to face Wilder’s side at a packed Bramall Lane, and give his prediction.
He’s tipping a narrow Blades victory after a cagey and attritional 90 minutes, either settled by a moment of magic or a mistake. Click through our photo gallery to see the players he has picked.
Let us know any changes you would make via Facebook or Twitter.