Click through our gallery to see if you can remember some real highs and lows for the Blades.
1. Blades photos from the noughties
Martin Smith celebrates scoring against Newcastle United in the FA Cup fourth round tie at St James' Park in January 2000. Photo: Michael Steele
2. Blades photos from the noughties
Neil Warnock is sent to the stands during the Nationwide First Division clash against Wolverhampton Wanderers at Molineux in September 2000. Photo: Laurence Griffiths
3. Blades photos from the noughties
Wayne Quinn battles with Wednesday's Efan Ekoku during the Worthington Cup third round match at Hillsborough in November 2000. Photo: Mark Thompson
4. Blades photos from the noughties
Carl Asaba scores against Wednesday at Hillsborough on April Fool's Day 2001. Photo: Ross Kinnaird